Highly structured homolog pairing reflects functional organization of the Drosophila genome

Authors :: Jumana AlHaj Abed
Jelena Erceg
Anton Goloborodko
Son C. Nguyen
Ruth B. McCole
Wren Saylor
Geoffrey Fudenberg
Bryan R. Lajoie
Job Dekker
Leonid A. Mirny
C.-ting Wu
Source :: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :: 2019
Publisher :: Nature Portfolio, 2019.
Abstract: Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and functional roles.

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