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The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Authors :
Christopher Noyes
Shunsuke Kitajima
Fengkai Li
Yusuke Suita
Saradha Miriyala
Shakson Isaac
Nagib Ahsan
Erik Knelson
Amir Vajdi
Tetsuo Tani
Tran C. Thai
Derek Xu
Junko Murai
Nikos Tapinos
Chiaki Takahashi
David A. Barbie
Mamiko Yajima
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug resistance.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.fe86a334b97d47fd9a7feeb2bdd23dba
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04444-7