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Mapping in mice the brain regions involved in the anxiolytic-like properties of α-casozepine, a tryptic peptide derived from bovine αs1-casein

Mapping in mice the brain regions involved in the anxiolytic-like properties of α-casozepine, a tryptic peptide derived from bovine αs1-casein

Authors :
Simon Benoit
Catherine Chaumontet
Jessica Schwarz
Céline Cakir-Kiefer
Daniel Tomé
Laurent Miclo
Source :
Journal of Functional Foods, Vol 38, Iss , Pp 464-473 (2017)
Publication Year :
2017
Publisher :
Elsevier, 2017.

Abstract

α-Casozepine, a bioactive peptide from milk casein, displays an anxiolytic-like activity in many species. Since its mode of action is still not elucidated, a study was conducted in Swiss mice to investigate c-Fos expression, a marker of neuronal activity, in different brain areas. After an intraperitoneal injection of α-casozepine (1 mg/kg), animals were placed either in a non-stressful or in an anxiety-inducing situation triggered with a light/dark box. No effect of α-casozepine on c-Fos expression was observed in the non-stressful situation. In the stressful situation, modulation of neuronal activity by α-casozepine was observed in different brain regions compared to that of vehicle. However, while diazepam, a benzodiazepine, modulated neuronal activity the same way in hippocampus, accumbens nucleus and hypothalamus, differences were observed in c-Fos expression in amygdala and prefrontal cortex compared to α-casozepine. These results strengthen the assumption that the anxiolytic mechanisms of α-casozepine differ partly of those of diazepam.

Details

Language :
English
ISSN :
17564646
Volume :
38
Issue :
464-473
Database :
Directory of Open Access Journals
Journal :
Journal of Functional Foods
Publication Type :
Academic Journal
Accession number :
edsdoj.fe7c92eba50c40b0a1df4eb85098cf86
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jff.2017.09.014