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Roles of AMPA receptors in social behaviors

Authors :
Qi Wei Xu
Amanda Larosa
Tak Pan Wong
Source :
Frontiers in Synaptic Neuroscience, Vol 16 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

As a crucial player in excitatory synaptic transmission, AMPA receptors (AMPARs) contribute to the formation, regulation, and expression of social behaviors. AMPAR modifications have been associated with naturalistic social behaviors, such as aggression, sociability, and social memory, but are also noted in brain diseases featuring impaired social behavior. Understanding the role of AMPARs in social behaviors is timely to reveal therapeutic targets for treating social impairment in disorders, such as autism spectrum disorder and schizophrenia. In this review, we will discuss the contribution of the molecular composition, function, and plasticity of AMPARs to social behaviors. The impact of targeting AMPARs in treating brain disorders will also be discussed.

Details

Language :
English
ISSN :
16633563
Volume :
16
Database :
Directory of Open Access Journals
Journal :
Frontiers in Synaptic Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.fe68ef6bd29147f5be73bcb513b680b2
Document Type :
article
Full Text :
https://doi.org/10.3389/fnsyn.2024.1405510