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Conquering hypertension in Vietnam: 12- month follow up results from a cluster-randomised controlled trialResearch in context

Authors :
Hoa L. Nguyen
Duc A. Ha
Oanh T. Tran
Van H. Phan
Cuc T. Nguyen
Giang H. Nguyen
Thang T. Nguyen
Thanh T. Le
Robert J. Goldberg
Bo Wang
Elena T. Tang
Germán Chiriboga
Henna Budhwani
Jeroan J. Allison
Source :
The Lancet Regional Health. Western Pacific, Vol 48, Iss , Pp 101123- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Summary: Background: Approximately 20% of adults in Vietnam have hypertension, and management of this chronic condition remains challenging. This study aimed to assess the effectiveness of a multicomponent intervention in reducing blood pressure (BP) in adults with uncontrolled hypertension. Methods: This cluster randomised controlled trial was conducted in sixteen communities (8 intervention and 8 comparison) in a rural setting in Vietnam (2017–2022). Consenting adults (aged ≥ 18 years) with uncontrolled hypertension were enrolled. Sixteen communities were equally randomised to an intervention or comparison group stratified by district. Consenting adults were assigned to study groups by community. The comparison arm received training sessions about hypertension prevention and management for health workers, and patient education materials. The intervention arm received training sessions about hypertension prevention and management for health workers, and patient education materials and three enhancement components including a storytelling intervention, home BP self-monitoring, and expanded community health worker services. The primary outcome was the difference in changes in patient's levels of systolic BP between the study groups over a 12-month follow-up period. Patients and outcome assessors were masked. Findings: A total of 671 patients (340: intervention, 331: comparison) were enrolled in the trial. The mean age was 66 years and 45% were men. At the 12-month follow-up, the mean systolic BP declined by 18.4 mmHg in the intervention group and 3.7 mmHg in the comparison group (differential decline of 14.7 mmHg [95% CI: 11.8–17.6]). The intervention group also achieved better BP control and medication adherence than the comparison group. There were no serious adverse events related to study participation. Interpretation: The results of this trial demonstrate that a multicomponent intervention can effectively reduce elevated BP in individuals with uncontrolled hypertension in Vietnam. Trial registration: This trial was registered at ClinicalTrials.gov, NCT03590691. Funding: National Heart, Lung, and Blood Institute.

Details

Language :
English
ISSN :
26666065
Volume :
48
Issue :
101123-
Database :
Directory of Open Access Journals
Journal :
The Lancet Regional Health. Western Pacific
Publication Type :
Academic Journal
Accession number :
edsdoj.fe664a692a5a4893999589b4f3b632d2
Document Type :
article
Full Text :
https://doi.org/10.1016/j.lanwpc.2024.101123