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Cooperative assembly of p97 complexes involved in replication termination

Authors :
Olga V. Kochenova
Sirisha Mukkavalli
Malavika Raman
Johannes C. Walter
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

This study describes how p97Ufd1-Npl4 and the UBA-UBX protein Ubxn7 disassemble vertebrate replisomes during replication termination, and it provides novel insights into how p97 complexes assemble with UBA-UBX proteins on ubiquitylated substrates

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.fe55a78b60a64c039bcf9df2bd3b5a2d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-34210-y