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Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis
- Source :
- Hepatology Communications, Vol 4, Iss 5, Pp 724-738 (2020)
- Publication Year :
- 2020
- Publisher :
- Wolters Kluwer Health/LWW, 2020.
-
Abstract
- Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways, upstream regulators, and therapeutic targets in PBC through integrated GWAS and messenger RNA (mRNA) microarray analysis. Disease pathways and upstream regulators were analyzed with ingenuity pathway analysis in data set 1 for GWASs (1,920 patients with PBC and 1,770 controls), which included 261 annotated genes derived from 6,760 single‐nucleotide polymorphisms (P 2 versus controls (P
- Subjects :
- Diseases of the digestive system. Gastroenterology
RC799-869
Subjects
Details
- Language :
- English
- ISSN :
- 2471254X
- Volume :
- 4
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Hepatology Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fe46dbbb09334b3f85f5095abc8398e3
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/hep4.1497