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Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

Authors :
Bing He
Ping Chen
Sonia Zambrano
Dina Dabaghie
Yizhou Hu
Katja Möller-Hackbarth
David Unnersjö-Jess
Gül Gizem Korkut
Emmanuelle Charrin
Marie Jeansson
Maria Bintanel-Morcillo
Anna Witasp
Lars Wennberg
Annika Wernerson
Bernhard Schermer
Thomas Benzing
Patrik Ernfors
Christer Betsholtz
Mark Lal
Rickard Sandberg
Jaakko Patrakka
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and highlight differences between mouse and human cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.fe04160ada134a20a0af7aef65e1f106
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22331-9