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Derangements in bone mineral parameters and bone mineral density in south Indian subjects on antiepileptic medications
- Source :
- Annals of Indian Academy of Neurology, Vol 17, Iss 3, Pp 272-276 (2014)
- Publication Year :
- 2014
- Publisher :
- Wolters Kluwer Medknow Publications, 2014.
-
Abstract
- Background: Although there are reports describing the association of alternations of bone and mineral metabolism in epileptic patients with long-term anticonvulsant therapy, there are only limited Indian studies which have looked at this aspect. Objectives: This study was done to compare the prevalence of changes in bone mineral parameters and bone mineral density (BMD) in ambulant individuals on long-term anticonvulsant therapy with age- and body mass index (BMI)-matched healthy controls. Materials and Methods: There were 55 men (on medications for more than 6 months) and age- and BMI-matched 53 controls. Drug history, dietary calcium intake (DCI), and duration of sunlight exposure were recorded. Bone mineral parameters and BMD were measured. Results: The control group had a significantly higher daily DCI with mean ± SD of 396 ± 91 mg versus 326 ± 101 mg (P = 0.007) and more sunlight exposure of 234 ± 81 vs 167 ± 69 min (P = 0.05). BMD at the femoral neck was significantly lower in cases (0.783 ± 0.105 g/cm 2 ) when compared to controls (0.819 ± 0.114 g/cm 2 ). Majority of the patients (61%) had low femoral neck BMD (P = 0.04). There was no significant difference in the proportion of subjects with vitamin D deficiency (
Details
- Language :
- English
- ISSN :
- 09722327 and 19983549
- Volume :
- 17
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Annals of Indian Academy of Neurology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fde325db79de4906b5eec9fac0a57014
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/0972-2327.138489