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Direct aortic route versus transaxillary route for transcatheter aortic valve replacement: a systematic review and meta-analysis
- Source :
- PeerJ, Vol 8, p e9102 (2020)
- Publication Year :
- 2020
- Publisher :
- PeerJ Inc., 2020.
-
Abstract
- Background The transfemoral route is contraindicated in nearly 10% of transcatheter aortic valve replacement (TAVR) candidates because of unsuitable iliofemoral vessels. Transaxillary (TAx) and direct aortic (DAo) routes are the principal nonfemoral TAVR routes; however, few studies have compared their outcomes. Methods We performed a systematic review and meta-analysis to compare the rates of mortality, stroke, and other adverse events of TAx and DAo TAVR. The study was prospectively registered with PROSPERO (registration number: CRD42017069788). We searched Medline, PubMed, Embase, and Cochrane databases for studies reporting the outcomes of DAo or TAx TAVR in at least 10 patients. Studies that did not use the Valve Academic Research Consortium definitions were excluded. We included studies that did not directly compare the two approaches and then pooled rates of events from the included studies for comparison. Results In total, 31 studies were included in the quantitative meta-analysis, with 2,883 and 2,172 patients in the DAo and TAx TAVR groups, respectively. Compared with TAx TAVR, DAo TAVR had a lower Society of Thoracic Surgery (STS) score, shorter fluoroscopic time, and less contrast volume use. The 30-day mortality rates were significantly higher in the DAo TAVR group (9.6%, 95% confidence interval (CI) = [8.4–10.9]) than in the TAx TAVR group (5.7%, 95% CI = [4.8–6.8]; P for heterogeneity
Details
- Language :
- English
- ISSN :
- 21678359
- Volume :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- PeerJ
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fd7198f6999c452cbc2a9f8873469dd4
- Document Type :
- article
- Full Text :
- https://doi.org/10.7717/peerj.9102