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Chrysosplenol D can inhibit the growth of prostate cancer by inducing reactive oxygen species and autophagy
- Source :
- Immunity, Inflammation and Disease, Vol 11, Iss 10, Pp n/a-n/a (2023)
- Publication Year :
- 2023
- Publisher :
- Wiley, 2023.
-
Abstract
- Abstract Objective To uncover the effects of chrysosplenol D (CHD) on the progression of prostate cancer in vitro as well as in mice. Methods DU145 and PC‐3 cells were treated with increasing doses of CHD for 24, 48, or 72 h. Cell Counting Kit‐8 (CCK‐8) and colony formation assays were conducted to confirm the effects of CHD on cell viability. Flow cytometry (FCM) and immunostaining assays showed the effects of CHD on cell apoptosis and oxidative stress. Immunoblot was performed to detect the effects of CHD on autophagy. Besides, tumor growth assays were conducted to confirm the role of CHD in tumor growth in mice. GraphPad 6.0 was used for statistical analysis. All data were represented as mean ± SD. p
Details
- Language :
- English
- ISSN :
- 20504527
- Volume :
- 11
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Immunity, Inflammation and Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fd2cae80a31f4b908b812ebda6baacd5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/iid3.1061