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Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Accurate recapitulation of human disease in animal models requires generation of complex and heterogeneous genetic variation. Here the authors combine RCAS-TVA with CRISPR-Cas9 to generate mouse models of cancer.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fd236016877346748003cdfce0070291
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-03731-w