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Presentation and Prognosis of Primary Expansile and Infiltrative Mucinous Carcinomas of the Ovary

Authors :
Marine Huin
Jerome Lorenzini
Flavie Arbion
Xavier Carcopino
Cyril Touboul
Yohann Dabi
Yohan Kerbage
Hélène Costaz
Lise Lecointre
Vincent Lavoué
Pierre-Adrien Bolze
Cyrille Huchon
Alexandre Bricou
Geoffroy Canlorbe
Camille Mimoun
Sofiane Bendifallah
Tristan Gauthier
Gilles Body
Lobna Ouldamer
Source :
Journal of Clinical Medicine, Vol 11, Iss 20, p 6120 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Objective: The aim of the present study was to evaluate evolution and prognosis of mucinous ovarian carcinomas (mOC), with respect to the two invasive patterns: expansile and infiltrative invasion. Methods: This was a descriptive, retrospective, multicenter study conducted in 13 French centres from 1 January 2001 to 31 December 2019. All patients operated on for epithelial ovarian neoplasia of the mucinous type (infiltrative/expansile) were included, whether the surgery was performed immediately or after neoadjuvant chemotherapy. Results: A total of 94 women with mucinous carcinomas were included in the present study. Mucinous tumours were divided into 35 expansile (37%) and 59 infiltrative (63%) mOC. There was a statistically significant difference in early and late stages at initial diagnosis between expansile and infiltrative mOC. None of the expansile mOC showed metastatic lymph nodes, whereas almost a quarter of the infiltrative mOC were metastatic to the pelvic/para-aortic region. There was a clear difference in RFS, in favour of expansile mOC, with 90% survival at 5 years, compared with 60% for infiltrative mOC. Conclusions: Although infiltrative and expansile mOC belong to the same histological family, they present many distinctions in clinical presentation, histological invasion, and disease course.

Details

Language :
English
ISSN :
20770383
Volume :
11
Issue :
20
Database :
Directory of Open Access Journals
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.fd12cdb3aa78499483e2f846328d6b47
Document Type :
article
Full Text :
https://doi.org/10.3390/jcm11206120