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Relationship of genetic causes and inhibin B in non obstructive azoospermia spermatogenic failure
- Source :
- BMC Medical Genetics, Vol 18, Iss 1, Pp 1-8 (2017)
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Abstract Background Chromosomal disorders in non obstructive azoospermia (NOA) may have an important influence on spermatogenesis, which may be reflected by the serum inhibin B levels. Till now, few studies have concerned the relationship of genetic causes and inhibin B in NOA. Methods In this retrospective study, 322 men with NOA in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. The level of follicle stimulating hormone (FSH), inhibin B, Y chromosome microdeletion test (YCMD) and karyotype were measured. Results Abnormal karyotypes were present in 38.5% of NOA, and YCMD were present in 18.0%, there was a high correlation between karyotypes and YCMD (χ2 = 11.892, P
Details
- Language :
- English
- ISSN :
- 14712350
- Volume :
- 18
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- BMC Medical Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fcf27533e9774e179e29a3d13ec1afa9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12881-017-0456-x