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Studies of Gene Variants Related to Inflammation, Oxidative Stress, Dyslipidemia, and Obesity: Implications for a Nutrigenetic Approach

Authors :
Maira Ladeia R. Curti
PatrĂ­cia Jacob
Maria Carolina Borges
Marcelo Macedo Rogero
Sandra Roberta G. Ferreira
Source :
Journal of Obesity, Vol 2011 (2011)
Publication Year :
2011
Publisher :
Hindawi Limited, 2011.

Abstract

Obesity is currently considered a serious public health issue due to its strong impact on health, economy, and quality of life. It is considered a chronic low-grade inflammation state and is directly involved in the genesis of metabolic disturbances, such as insulin resistance and dyslipidemia, which are well-known risk factors for cardiovascular disease. Furthermore, there is evidence that genetic variation that predisposes to inflammation and metabolic disturbances could interact with environmental factors, such as diet, modulating individual susceptibility to developing these conditions. This paper aims to review the possible interactions between diet and single-nucleotide polymorphisms (SNPs) in genes implicated on the inflammatory response, lipoprotein metabolism, and oxidative status. Therefore, the impact of genetic variants of the peroxisome proliferator-activated receptor-(PPAR-)gamma, tumor necrosis factor-(TNF-)alpha, interleukin (IL)-1, IL-6, apolipoprotein (Apo) A1, Apo A2, Apo A5, Apo E, glutathione peroxidases 1, 2, and 4, and selenoprotein P exposed to variations on diet composition is described.

Subjects

Subjects :
Internal medicine
RC31-1245

Details

Language :
English
ISSN :
20900708 and 20900716
Volume :
2011
Database :
Directory of Open Access Journals
Journal :
Journal of Obesity
Publication Type :
Academic Journal
Accession number :
edsdoj.fcef5f69245740d19564459e32710c72
Document Type :
article
Full Text :
https://doi.org/10.1155/2011/497401