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Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice

Authors :
Siqi Li
Kazuko Tajiri
Nobuyuki Murakoshi
DongZhu Xu
Saori Yonebayashi
Yuta Okabe
Zixun Yuan
Duo Feng
Keiko Inoue
Kazuhiro Aonuma
Yuzuno Shimoda
Zoughu Song
Haruka Mori
Honglan Huang
Kazutaka Aonuma
Masaki Ieda
Source :
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1426 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Programmed death ligand 2 (PD-L2) is the second ligand of programmed death 1 (PD-1) protein. In autoimmune myocarditis, the protective roles of PD-1 and its first ligand programmed death ligand 1 (PD-L1) have been well documented; however, the role of PD-L2 remains unknown. In this study, we report that PD-L2 deficiency exacerbates myocardial inflammation in mice with experimental autoimmune myocarditis (EAM). EAM was established in wild-type (WT) and PD-L2-deficient mice by immunization with murine cardiac myosin peptide. We found that PD-L2-deficient mice had more serious inflammatory infiltration in the heart and a significantly higher myocarditis severity score than WT mice. PD-L2-deficient dendritic cells (DCs) enhanced CD4+ T cell proliferation in the presence of T cell receptor and CD28 signaling. These data suggest that PD-L2 on DCs protects against autoreactive CD4+ T cell expansion and severe inflammation in mice with EAM.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
22
Issue :
3
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.fcee9012b3e54960b88c636301c2f552
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms22031426