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Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Minichromosome maintenance protein 10 (MCM10) is critical for eukaryotic DNA replication. Here, by modelling MCM10 variants in human cell lines, the authors reveal a mechanism of MCM10-associated disease, finding that loss of MCM10 function constrains telomerase activity.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fcda6dd35e9949f888622bfe0a813011
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-21878-x