Back to Search
Start Over
The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
- Source :
- Clinical and Developmental Immunology, Vol 2012 (2012)
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution. In this paper, we extended our analysis to a gene variation at the 5′ end on the -156G>GG single nucleotide polymorphism (SNP) and replicated our previous findings at the 3′ end on the +1239A>C SNP. We found that only +1239A>C SNP displayed a statistically significant association with MS development, but both +1239A>C and -156G>GG had an influence on MS progression, since patients homozygous for both +1239A and −156GG alleles displayed slower progression of disability and slower switch to secondary progression than those carrying +1239C and/or −156G and those homozygous for +1239A only. Moreover, patients homozygous for +1239A also displayed a significantly lower relapse rate than those carrying +1239C, which is in line with the established role of OPN in MS relapses.
- Subjects :
- Immunologic diseases. Allergy
RC581-607
Subjects
Details
- Language :
- English
- ISSN :
- 17402522 and 17402530
- Volume :
- 2012
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fcd5b8a62ae742f7932a6f9ad6c3e5ff
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2012/212893