Back to Search
Start Over
Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea
- Source :
- Clinical Pediatric Hematology-Oncology, Vol 30, Iss 1, Pp 11-20 (2023)
- Publication Year :
- 2023
- Publisher :
- The Korean Society of Pediatric Hematology-Oncology, 2023.
-
Abstract
- Background : : Acute complications within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) can increase immediate mortality as well as the risk of chronic complications and morbidity. A comprehensive review collecting systemic complications following transplantation would be important in pediatric patients. Methods : : We report a retrospective study of pediatric patients who underwent allogeneic HSCT during the 11 years (2009-2020), and their acute complications after transplantation within 100 days. A total 227 pediatric patients' (90 females, 137 males) data were collected. Results : : Among the patients, 62.6% (N=142) suffered from acute graft-versus-host disease, and 118 (52.0%) patients had an acute infection. Pulmonary complications occurred in 52 (22.9%) patients followed by hepatic sinusoidal obstruction syndrome in 30 (18.1%) patients. In the study, 19 died within the first 100 days after HSCT (8.4%), and the 5-year overall survival rate of the patients was 65.4%. Conclusion : : This study widens the understanding of acute toxicities of pediatric HSCT. A significant number of children still have experienced a variety of acute infectious or non-infectious complications after allogeneic HSCT that contribute to morbidity and mortality. Therefore, continuous efforts are needed to reduce them.
Details
- Language :
- English, Korean
- ISSN :
- 22335250
- Volume :
- 30
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical Pediatric Hematology-Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fcc18d1a91540c7a516671c2bb6b56d
- Document Type :
- article
- Full Text :
- https://doi.org/10.15264/cpho.2023.30.1.11