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Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period
- Source :
- Turkish Journal of Hematology, Vol 33, Iss 1, Pp 8-14 (2016)
- Publication Year :
- 2016
- Publisher :
- Galenos Publishing House, 2016.
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Abstract
- INTRODUCTION: Nuclear factor kappa B (NF-κB) is an important transcription factor in cancer and NF-κB activation has been seen in angiogenesis, tumor progression, and metastasis. Relationships between specific NF-κB gene networks, leukemogenesis, and radiation exposure are still unknown. Our aim was to study the expression levels of the NF-κB1, NF-κB2, and Rel genes in hematological malignancies in the post-Chernobyl period. METHODS: We analyzed gene expression levels of NF- κB1, NF-κB2, and Rel in 49 B-cell chronic lymphocytic leukemia, 8 B-cell non-Hodgkin's lymphoma, 3 acute myeloid leukemia, 3 chronic myeloid leukemia, 2 hairy cell leukemia, 2 myelodysplastic syndrome, and 2 T-cell large granular lymphocytic leukemia patients using realtime polymerase chain reaction. RESULTS: Expression levels of NF-κB1, NF-κB2, and Rel genes were found to be deregulated. DISCUSSION AND CONCLUSION: These results could be accepted as specific gene traces to radiation-induced leukemia or as potential candidates for new diagnostic biomarker studies. Larger experiments and non-exposed control malignant cell populations are needed to clarify these suggestions.
Details
- Language :
- English
- ISSN :
- 13085263
- Volume :
- 33
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Turkish Journal of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fc8e2bebff7443b8afd6bf1126d6f84f
- Document Type :
- article
- Full Text :
- https://doi.org/10.4274/tjh.2014.0190