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Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins

Authors :
Tanya R. McKitrick
Steffen M. Bernard
Alexander J. Noll
Bernard C. Collins
Christoffer K. Goth
Alyssa M. McQuillan
Jamie Heimburg-Molinaro
Brantley R. Herrin
Ian A. Wilson
Max D. Cooper
Richard D. Cummings
Source :
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

McKitrick et al engineer and characterize a novel lamprey antibody that recognizes terminal sulfated galactose epitopes on mammalian glycoproteins. This provides a new tool for the exploration of glycoprotein sulfation in mammalian cells, which could aid in the understanding of its functional role and potentially lead to identification of disease biomarkers.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
4
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.fc44f226d9cf4dce8756ecf26052d69b
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-021-02199-7