Back to Search
Start Over
Effect of environmental phthalate exposure on pregnancy duration and birth outcomes
- Source :
- International Journal of Occupational Medicine and Environmental Health, Vol 29, Iss 4, Pp 683-697 (2016)
- Publication Year :
- 2016
- Publisher :
- Nofer Institute of Occupational Medicine, 2016.
-
Abstract
- Objectives: The objective of this study was to evaluate the impact of phthalate exposure on pregnancy duration and birth outcomes based on the Polish Mother and Child Cohort (REPRO_PL). Material and Methods: Phthalate exposure was determined by measuring 11 phthalate metabolites (mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono‑ (2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP)) in the urine collected from 165 mothers during the third trimester of pregnancy by high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The following measures at birth were considered: gestational age, birth weight, length as well as head and chest circumference. Results: Pregnancy duration was inversely associated with natural log concentrations (μg/g creatinine) of MEP (standardized regression coefficient (β) = –0.2, p = 0.04) after adjustment for a variety of confounders. Significant impact of MOiNP on head circumference (β = –0.1, p = 0.05) was also observed. Conclusions: The study findings add further support to the hypothesis that phthalate exposure may be associated with shorter pregnancy duration and a decreased head circumference, and underscore importance of public health interventions to reduce that exposure.
Details
- Language :
- English
- ISSN :
- 12321087 and 1896494X
- Volume :
- 29
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Occupational Medicine and Environmental Health
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fbb080eacf434fe7be44f5ee9bcd1a27
- Document Type :
- article
- Full Text :
- https://doi.org/10.13075/ijomeh.1896.00691