Back to Search Start Over

Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways

Authors :
Jung-Il Kang
Min-Kyoung Kim
Ji-Hyeok Lee
You-Jin Jeon
Eun-Kyoung Hwang
Young-Sang Koh
Jin-Won Hyun
Soon-Young Kwon
Eun-Sook Yoo
Hee-Kyoung Kang
Source :
Marine Drugs, Vol 15, Iss 5, p 130 (2017)
Publication Year :
2017
Publisher :
MDPI AG, 2017.

Abstract

In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significantly accelerated anagen initiation in vivo. Moreover, we found that U. peterseniana extract was able to open the KATP channel, which may contribute to increased hair growth. The U. peterseniana extract decreased 5α-reductase activity and markedly increased the proliferation of dermal papilla cells, a central regulator of the hair cycle. The U. peterseniana extract increased the levels of cell cycle proteins, such as Cyclin D1, phospho(ser780)-pRB, Cyclin E, phospho-CDK2, and CDK2. The U. peterseniana extract also increased the phosphorylation of ERK and the levels of Wnt/β-catenin signaling proteins such as glycogen synthase kinase-3β (GSK-3β) and β-catenin. These results suggested that the U. peterseniana extract had the potential to influence hair growth by dermal papilla cells proliferation through the activation of the Wnt/β-catenin and ERK pathways. We isolated a principal of the U. peterseniana extract, which was subsequently identified as apo-9′-fucoxanthinone, a trichogenic compound. The results suggested that U. peterseniana extract may have a pivotal role in the treatment of alopecia.

Details

Language :
English
ISSN :
16603397 and 15050130
Volume :
15
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.fb53a047ea474c5bbf990c0863cfc2cc
Document Type :
article
Full Text :
https://doi.org/10.3390/md15050130