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An Amidase Contributes to Full Virulence of Sclerotinia sclerotiorum
- Source :
- International Journal of Molecular Sciences, Vol 23, Iss 19, p 11207 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Sclerotinia sclerotiorum is one of the most notorious and ubiquitous soilborne plant pathogens, causing serious economic losses to a large number of hosts worldwide. Although virulence factors have been identified in this filamentous fungus, including various cell-wall-degrading enzymes, toxins, oxalic acids and effectors, our understanding of its virulence strategies is far from complete. To explore novel factors contributing to disease, a new pipeline combining forward genetic screening and next-generation sequencing was utilized in this study. Analysis of a hypovirulent mutant revealed that a mutation in an amidase-encoding gene, Sscle_10g079050, resulted in reduced virulence. This is a first report on the contribution of an amidase to fungal virulence, likely through affecting oxalic acid homeostasis.
Details
- Language :
- English
- ISSN :
- 23191120, 14220067, and 16616596
- Volume :
- 23
- Issue :
- 19
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.faebf7ce4c88486bade9e7f035f086ed
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ijms231911207