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Primary failure of tooth eruption: Etiology and management
- Source :
- Japanese Dental Science Review, Vol 58, Iss , Pp 258-267 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Primary failure of eruption (PFE) is a rare disorder defined as incomplete tooth eruption despite the presence of a clear eruption pathway. PFE is known to be caused by rare variants in the parathyroid hormone 1 receptor gene (PTH1R). Although several PTH1R variants have been reported, the etiology of PFE remains unclear. However, important studies that help elucidate the pathology of PFE have recently been published. The purpose of this review is to summarize current treatment options, clinical symptoms or phenotypes for diagnosis, genetic information including solid evidence in mouse disease models and disease-specific induced pluripotent stem cells, thus approaching the etiology of PFE from the perspective of the latest research.
Details
- Language :
- English
- ISSN :
- 18827616
- Volume :
- 58
- Issue :
- 258-267
- Database :
- Directory of Open Access Journals
- Journal :
- Japanese Dental Science Review
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fa43c58524354f5490c5bc8fe9a5c706
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jdsr.2022.08.002