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Sex hormone replacement therapy for patients with Prader-Willi syndrome

Authors :
WANG Liang, WANG Xi, NIE Min, WU Xueyan, MAO Jiangfeng
Source :
Jichu yixue yu linchuang, Vol 43, Iss 4, Pp 632-635 (2023)
Publication Year :
2023
Publisher :
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College., 2023.

Abstract

Objective To analyze the sex hormonal therapy present status in patients with Prader-Willi syndrome (PWS) and to provide guidance for the future sex hormone application. Methods Pubertal development, abnormal behavior, bone mineral density, sex hormone treatment and parents' attitude to sex hormone application were analyzed by a self-designed questionnaire. Results A total of 41 PWS patients were included (21 males and 20 females) and the median age was 15 years old (13-24 years). For boys, all had cryptorchidism, of which 6 patients (28.6%) had no pubertal development. None of the patients were receiving additional androgen therapy. For girls, 13 (65%) had primary amenorrhea. Only 2 patients had received or was continuing estrogen replacement therapy. Considering the inconveniences of drug application and other reasons, 16 cases (39%) of parents were unwilling to undergo sex hormone therapy. Conclusions Almost all patients with PWS are hypogonadism. Lack of medical recommendations and limited knowledge on sex hormones for their parents, may contribute to low prevalence of sex hormone therapy in this population.

Details

Language :
Chinese
ISSN :
10016325
Volume :
43
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Jichu yixue yu linchuang
Publication Type :
Academic Journal
Accession number :
edsdoj.fa3fbb6fa8334cd5b4b8bba38cb4ee76
Document Type :
article
Full Text :
https://doi.org/10.16352/j.issn.1001-6325.2023.04.0632