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Sex hormone replacement therapy for patients with Prader-Willi syndrome
- Source :
- Jichu yixue yu linchuang, Vol 43, Iss 4, Pp 632-635 (2023)
- Publication Year :
- 2023
- Publisher :
- Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College., 2023.
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Abstract
- Objective To analyze the sex hormonal therapy present status in patients with Prader-Willi syndrome (PWS) and to provide guidance for the future sex hormone application. Methods Pubertal development, abnormal behavior, bone mineral density, sex hormone treatment and parents' attitude to sex hormone application were analyzed by a self-designed questionnaire. Results A total of 41 PWS patients were included (21 males and 20 females) and the median age was 15 years old (13-24 years). For boys, all had cryptorchidism, of which 6 patients (28.6%) had no pubertal development. None of the patients were receiving additional androgen therapy. For girls, 13 (65%) had primary amenorrhea. Only 2 patients had received or was continuing estrogen replacement therapy. Considering the inconveniences of drug application and other reasons, 16 cases (39%) of parents were unwilling to undergo sex hormone therapy. Conclusions Almost all patients with PWS are hypogonadism. Lack of medical recommendations and limited knowledge on sex hormones for their parents, may contribute to low prevalence of sex hormone therapy in this population.
- Subjects :
- prader-willi syndrome
hypogonadism
hormone replacement therapy
Medicine
Subjects
Details
- Language :
- Chinese
- ISSN :
- 10016325
- Volume :
- 43
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Jichu yixue yu linchuang
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fa3fbb6fa8334cd5b4b8bba38cb4ee76
- Document Type :
- article
- Full Text :
- https://doi.org/10.16352/j.issn.1001-6325.2023.04.0632