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IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 and macrophage differentiation/reparative function required for club cell regeneration.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.fa2aff3dc9744c0adab9ba6f648aaa3
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-18466-w