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Efficacy of the Second COVID-19 Vaccine Booster Dose in the Elderly
- Source :
- Vaccines, Vol 11, Iss 2, p 213 (2023)
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- Background: We analyzed coronavirus disease 2019 (COVID-19) vaccine efficacy in older persons who received the second booster compared to unvaccinated people and those receiving only a single COVID-19 vaccine booster. Methods: We collected information on vaccine efficacy from the ongoing Italian nationwide COVID-19 vaccination campaign in subjects aged 80 years or older from official data published by the Italian National Institute of Health. Results: The second vaccine booster maintained high effectiveness against adverse COVID-19 outcomes such as hospitalization, intensive care unit admission and death (i.e., between 77 and 86%), and also showed around 10% higher efficacy than the single booster. Nonetheless, the efficacy of the second vaccine booster declined over time, decreasing by 33–46% when assessed at >120 days from administration. Conclusions: The results of our ad interim analysis of the ongoing Italian nationwide COVID-19 vaccination campaign suggest that regular boosting with COVID-19 vaccines may be advisable in older persons.
- Subjects :
- COVID-19
SARS-CoV-2
vaccination
booster
elderly
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 2076393X
- Volume :
- 11
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Vaccines
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f9f8e2706dd44a0dbafb924f487486ee
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/vaccines11020213