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Plasma Long Noncoding RNA LeXis is a Potential Diagnostic Marker for Non-Alcoholic Steatohepatitis

Authors :
Jung Gil Park
Gyeonghwa Kim
Se Young Jang
Yu Rim Lee
Eunhye Lee
Hye Won Lee
Man-Hoon Han
Jae Min Chun
Young Seok Han
Jun Sik Yoon
Min Kyu Kang
Young Oh Kweon
Won Young Tak
Soo Young Park
Keun Hur
Source :
Life, Vol 10, Iss 10, p 230 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Non-invasive diagnostic markers are needed to ease the diagnosis of non-alcoholic steatohepatitis (NASH) among patients with non-alcoholic fatty liver disease (NAFLD). The long noncoding RNA (lncRNA) LeXis is related to cholesterol metabolism and hepatic steatosis in mice, and its batch genome conversion in humans is TCONS_00016452. Here, we aimed to evaluate the potential of lncRNA LeXis as a non-invasive diagnostic marker for NASH. We analyzed a total of 44 NAFLD patients whose diagnosis was confirmed by a pathologist through analysis of a percutaneous liver biopsy. The expression of LeXis in the plasma of NAFLD patients with and without NASH was compared using quantitative real-time polymerase chain reaction. The expression of plasma LeXis was significantly higher in patients with NASH than in those with NAFL (8.2 (5.0–14.9); 4.6 (4.0–6.6), p = 0.025). The area under the receiver operating characteristic curve was 0.743 (95% CI 0.590–0.895, p < 0.001), and a sensitivity of 54.3% and specificity of 100% could be achieved for NASH diagnosis. Low LeXis was independently associated with NASH diagnosis in patients with NAFLD (p = 0.0349, odds ratio = 22.19 (5% CI, 1.25–395.22)). Therefore, circulating lncRNA LeXis could be a potential non-invasive diagnostic biomarker for NASH.

Details

Language :
English
ISSN :
20751729
Volume :
10
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Life
Publication Type :
Academic Journal
Accession number :
edsdoj.f9dd0f77411c40a0bb5a014f46c50ee6
Document Type :
article
Full Text :
https://doi.org/10.3390/life10100230