Back to Search Start Over

Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential Targets

Authors :
Li Li
Rui Ni
Ziwei Li
Yue Ming
Li Liu
Dan Peng
Yongqing Cai
Yuanlin Wu
Tingting Jiang
Yanping Li
Yao Liu
Source :
Frontiers in Bioscience-Landmark, Vol 27, Iss 11, p 313 (2022)
Publication Year :
2022
Publisher :
IMR Press, 2022.

Abstract

Platelets are small, anucleate cellular fragments, which are produced by megakaryocytes, and play a key role in hemostasis and thrombus formation. The differentiation of megakaryocytes from hematopoietic stem cells in bone marrow and the development of megakaryocytes into platelets is a complex process. Various regulatory factorsin megakaryopoiesis including cytokines, growth factors, transcription factors, and gene expression, are all involved in the process of thrombocytopoiesis and play distinct roles in different stages of megakaryocytes development. In this review, we summarize the current state of knowledge ofmultiple regulatory factors including the TPO/Mpl signaling pathway, transcription factors, RasGTPases family, estrogen, and microRNAs. Altogether, we aimed to discuss more molecular mechanisms of megakaryocytes differentiation and maturation, and possess a better understanding of platelet formation.

Details

Language :
English
ISSN :
27686701
Volume :
27
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Frontiers in Bioscience-Landmark
Publication Type :
Academic Journal
Accession number :
edsdoj.f9d32be1c2f74d54b26c2ea542724067
Document Type :
article
Full Text :
https://doi.org/10.31083/j.fbl2711313