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Apnea of Prematurity and Oxidative Stress: Potential Implications

Authors :
Lauren Thompson
Joseph W. Werthammer
David Gozal
Source :
Antioxidants, Vol 13, Iss 11, p 1304 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Apnea of prematurity (AOP) occurs in 85% of neonates ≤34 weeks of gestational age. AOP is frequently associated with intermittent hypoxia (IH). This narrative review reports on the putative relationship of AOP with IH and the resulting oxidative stress (OS). Preterm infants are susceptible to OS due to an imbalance between oxidant and antioxidant systems with the excessive free radical load leading to serious morbidities that may include retinopathy of prematurity, bronchopulmonary dysplasia, and neurodevelopmental delay. Current therapeutic approaches to minimize the adverse effects of AOP and optimize oxygen delivery include noninvasive ventilation and xanthine inhibitor therapy, but these approaches have only been partially successful in decreasing the incidence of AOP and associated morbidities.

Details

Language :
English
ISSN :
20763921
Volume :
13
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Antioxidants
Publication Type :
Academic Journal
Accession number :
edsdoj.f9b8c854cb0d459f8a03940b5eba20af
Document Type :
article
Full Text :
https://doi.org/10.3390/antiox13111304