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Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Authors :
Clint L. Miller
Milos Pjanic
Ting Wang
Trieu Nguyen
Ariella Cohain
Jonathan D. Lee
Ljubica Perisic
Ulf Hedin
Ramendra K. Kundu
Deshna Majmudar
Juyong B. Kim
Oliver Wang
Christer Betsholtz
Arno Ruusalepp
Oscar Franzén
Themistocles L. Assimes
Stephen B. Montgomery
Eric E. Schadt
Johan L.M. Björkegren
Thomas Quertermous
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Coronary heart disease is the leading cause of death worldwide with multiple environmental and genetic risk factors. Here the authors integrate genomic, epigenomic and transcriptomic mapping to elucidate causal variation and mechanisms of known genetic associations.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 92463932
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f9af3cf26bf44b0ab0e9246393278dd
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms12092