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Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Authors :
Kira J. Stanzick
Yong Li
Pascal Schlosser
Mathias Gorski
Matthias Wuttke
Laurent F. Thomas
Humaira Rasheed
Bryce X. Rowan
Sarah E. Graham
Brett R. Vanderweff
Snehal B. Patil
VA Million Veteran Program
Cassiane Robinson-Cohen
John M. Gaziano
Christopher J. O’Donnell
Cristen J. Willer
Stein Hallan
Bjørn Olav Åsvold
Andre Gessner
Adriana M. Hung
Cristian Pattaro
Anna Köttgen
Klaus J. Stark
Iris M. Heid
Thomas W. Winkler
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Identifying causal variants and genes in genome-wide association studies remains a challenge, an issue that is ameliorated with larger sample sizes. Here the authors meta-analyze kidney function genome-wide association studies to identify new loci and fine-map loci to home in on variants and genes involved in kidney function.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f9a7445b1e5c4729b2f89352fcb65ca1
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-24491-0