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Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates
- Source :
- EJNMMI Research, Vol 7, Iss 1, Pp 1-5 (2017)
- Publication Year :
- 2017
- Publisher :
- SpringerOpen, 2017.
-
Abstract
- Abstract Background The 18-kDa translocator protein (TSPO) is an important target for assessing neuroimmune function in brain with positron-emission tomography (PET) imaging. The goal of this work was to assess two [11C]PBR28 imaging paradigms for measuring dynamic microglia changes in Macaca mulatta. Methods Dynamic [11C]PBR28 PET imaging data with arterial blood sampling were acquired to quantify TSPO levels as [11C]PBR28 V T. Scans were acquired at three timepoints: baseline, immediately post-drug, and prolonged post-drug. Results In one animal, a colony-stimulating factor 1 receptor kinase inhibitor, previously shown to deplete brain microglia, reduced [11C]PBR28 V T in brain by 46 ± 3% from baseline, which recovered after 12 days to 7 ± 5% from baseline. In a different animal, acute lipopolysaccharide administration, shown to activate brain microglia, increased [11C]PBR28 V T in brain by 39 ± 9% from baseline, which recovered after 14 days to −11 ± 3% from baseline. Conclusions These studies provide preliminary evidence of complementary paradigms to assess microglia dynamics via in vivo TSPO imaging.
Details
- Language :
- English
- ISSN :
- 2191219X
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- EJNMMI Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f9924aaf20a4a3cb598404a9e455730
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13550-017-0305-0