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SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner

Authors :
Tatiana Dandolini Saccon
Felippe Mousovich-Neto
Raissa Guimarães Ludwig
Victor Corasolla Carregari
Ana Beatriz dos Anjos Souza
Amanda Stephane Cruz dos Passos
Matheus Cavalheiro Martini
Priscilla Paschoal Barbosa
Gabriela Fabiano de Souza
Stéfanie Primon Muraro
Julia Forato
Mariene Ribeiro Amorim
Rafael Elias Marques
Flavio Protasio Veras
Ester Barreto
Tiago Tomazini Gonçalves
Isadora Marques Paiva
Narayana P. B. Fazolini
Carolina Mie Kawagosi Onodera
Ronaldo Bragança Martins Junior
Paulo Henrique Cavalcanti de Araújo
Sabrina Setembre Batah
Rosa Maria Mendes Viana
Danilo Machado de Melo
Alexandre Todorovic Fabro
Eurico Arruda
Fernando Queiroz Cunha
Thiago Mattar Cunha
Marco Antônio M. Pretti
Bradley Joseph Smith
Henrique Marques-Souza
Thiago L. Knittel
Gabriel Palermo Ruiz
Gerson S. Profeta
Tereza Cristina Minto Fontes-Cal
Mariana Boroni
Marco Aurélio Ramirez Vinolo
Alessandro S. Farias
Pedro Manoel M. Moraes-Vieira
Joyce Maria Annichino Bizzacchi
Tambet Teesalu
Felipe David Mendonça Chaim
Everton Cazzo
Elinton Adami Chaim
José Luiz Proença-Módena
Daniel Martins-de-Souza
Mariana Kiomy Osako
Luiz Osório Leiria
Marcelo A. Mori
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Visceral adiposity is a risk factor for severe COVID-19, and infection of adipose tissue by SARS-CoV-2 has been reported. Here the authors confirm that human adipose tissue is a possible site for SARS-CoV-2 infection, but the degree of adipose tissue infection and the way adipocytes respond to the virus depend on the adipose tissue depot and the viral strain.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f9905b4afe84326b4de5ee835598f79
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-33218-8