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Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura

Authors :
Heng-Le Wei
Tian Tian
Gang-Ping Zhou
Jin-Jin Wang
Xi Guo
Yu-Chen Chen
Yu-Sheng Yu
Xindao Yin
Junrong Li
Hong Zhang
Source :
Neural Plasticity, Vol 2022 (2022)
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Background. Visual symptoms are common in patients with migraine, even in interictal periods. The purpose was to assess the association between dynamic functional connectivity (dFC) of the visual cortex and clinical characteristics in migraine without aura (MwoA) patients. Methods. We enrolled fifty-five MwoA patients as well as fifty gender- and age-matched healthy controls. Regional visual cortex alterations were investigated using regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF). Then, significant regions were selected as seeds for conducting dFC between the visual cortex and the whole brain. Results. Relative to healthy controls, MwoA patients exhibited decreased ReHo and ALFF values in the right lingual gyrus (LG) and increased ALFF values in the prefrontal cortex. The right LG showed abnormal dFC within the visual cortex and with other core brain networks. Additionally, ReHo values for the right LG were correlated with duration of disease and ALFF values of the right inferior frontal gyrus and middle frontal gyrus were correlated with headache frequency and anxiety scores, respectively. Moreover, the abnormal dFC of the right LG with bilateral cuneus was positively correlated with anxiety scores. Conclusions. The dFC abnormalities of the visual cortex may be involved in pain integration with multinetworks and associated with anxiety disorder in episodic MwoA patients.

Details

Language :
English
ISSN :
16875443
Volume :
2022
Database :
Directory of Open Access Journals
Journal :
Neural Plasticity
Publication Type :
Academic Journal
Accession number :
edsdoj.f9321b649b4b4784be2a82b82b8e57
Document Type :
article
Full Text :
https://doi.org/10.1155/2022/9941832