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Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

Authors :
Kenneth C. P. Cheung
Silvia Fanti
Claudio Mauro
Guosu Wang
Anitha S. Nair
Hongmei Fu
Silvia Angeletti
Silvia Spoto
Marta Fogolari
Francesco Romano
Dunja Aksentijevic
Weiwei Liu
Baiying Li
Lixin Cheng
Liwen Jiang
Juho Vuononvirta
Thanushiyan R. Poobalasingam
David M. Smith
Massimo Ciccozzi
Egle Solito
Federica M. Marelli-Berg
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f928ac93a0a4597a8951f70e8733d1b
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-17329-8