Back to Search Start Over

The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update

Authors :
Robert Aurelian Tiucă
Oana Mirela Tiucă
Ionela Maria Pașcanu
Source :
Biomedicines, Vol 11, Iss 4, p 1075 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Thyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades. It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the most common histological type, followed by follicular carcinoma. Associations between genetic polymorphisms and thyroid cancer have been investigated over the years and are an intriguing topic for the scientific world. To date, the results of associations of single nucleotide polymorphisms, the most common genetic variations in the genome, with thyroid cancer have been inconsistent, but many promising results could potentially influence future research toward developing new targeted therapies and new prognostic biomarkers, thus consolidating a more personalized management for these patients. This review focuses on emphasizing the existing literature data regarding genetic polymorphisms investigated for their potential association with differentiated thyroid cancer and highlights the opportunity of using genetic variations as biomarkers of diagnosis and prognosis for thyroid cancer patients.

Details

Language :
English
ISSN :
22279059
Volume :
11
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.f9031aace5604ed38d9d54c6db7b91f8
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines11041075