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Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

Authors :
Hamish T. J. Gilbert
Venkatesh Mallikarjun
Oana Dobre
Mark R. Jackson
Robert Pedley
Andrew P. Gilmore
Stephen M. Richardson
Joe Swift
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Cells must be robust to the mechanical demands of their environments. Here, Gilbert et al. expose cells to high-intensity strain cycling and use proteomics to identify a protein, SUN2, that behaves as a strain-induced breakpoint that can decouple the nucleoskeleton from the cytoskeleton.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f8f759b44d8640cea035f511934e57db
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11923-1