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Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement
- Source :
- Basrah Journal of Surgery, Vol 28, Iss 2, Pp 15-20 (2022)
- Publication Year :
- 2022
- Publisher :
- university of basrah, 2022.
-
Abstract
- Using anterior segment optical coherence tomography (AS-OCT) to compare the depth of corneal demarcation line (DL) after corneal collagen cross-linking (CXL) with subtotal versus customized corneal epithelium debridement. Design: Prospective multi centric case-control study. Materials and Methods: The study enrolled 18 patients with bilateral progressive keratoconus. Both eyes treated by CXL using 3 mW/cm2 / 30 minutes setting. One eye with subtotal epithelial debridement ( about 9 mm diameter) and the contralateral eye with customized debridement ( approximately 1 mm single horizontal scratch ). One month postoperatively, patients had AS-OCT imaging to detect and measure the depth of DL. Results: Patients’ age mean was 25.17 years +/- 4.81 SD . Epithelial healing completed with in 3-7 days in conventional treatment group and demarcation line was evident in 16 eyes ( 89% ) with a mean depth of 290.31 micro m while in customized epi-off treatment group, the epithelial healing lasted less than 24 hours and DL was detectable in 10 patients ( 55.5 % ) with a mean DL depth of 221 micro m with a statistically significant difference ( p < 0.05 ) Subjective postoperative pain graded as “moderate to severe” in about 77% of eyes underwent 9 mm epi-off CXL compared with 55% of those with customized treatment. Conclusions: Although the DL if found in majority cases, but the shallow location in customized corneal debridement cases questioned the efficacy of this technique despite the quick re-epithelialization and less postoperative pain that accompanied it.
- Subjects :
- cornea
؛collagen cross-linking
؛debridement
Medicine
Science
Subjects
Details
- Language :
- English
- ISSN :
- 16833589 and 2409501X
- Volume :
- 28
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Basrah Journal of Surgery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f8b7125e7bb94d03a0e61ed58d02edca
- Document Type :
- article
- Full Text :
- https://doi.org/10.33762/bsurg.2022.136657.1032