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Hepatic encephalopathy- Clinical profile and patient outcome

Authors :
Dilipkumar
Juhi R
Karthikayan R. K.
Yoganathan Chidambaram
Clement Jenil Dhas
Sujithkumar S
Source :
Journal of Krishna Institute of Medical Sciences University, Vol 13, Iss 2, Pp 136-151 (2024)
Publication Year :
2024
Publisher :
Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, 2024.

Abstract

Background: Hepatic Encephalopathy (HE) is a challenging and prevalent complication that arises in the context of liver cirrhosis characterized by cognitive dysfunction resulting from liver insufficiency and/or the development of portosystemic shunts. Aim and Objectives: To investigate the clinical characteristics, precipitating factors, and clinical outcomes of HE with liver disease in patients admitted to a tertiary care center. Material and Methods: A retrospective observational study at a hospital reviewed records of 100 HE patients admitted from Jan-Dec 2022. Data on demographics, clinical features, lab results, stay duration, and outcomes were collected from past records. Statistical analysis explored links between outcomes, symptoms, lab results, causes, Model for End-Stage Liver Disease (MELD) scores, and hospital duration (p < 0.05 considered significant). Patients were tracked until discharge or death. Results: Most HE cases were males (75.8%) and aged 21-87. Key symptoms were abdominal distension (62.6%) and jaundice (60.4%). Jaundice impacted outcomes (p = 0.045); infections triggered 39.6% of cases, impacting outcomes (p = 0.039). High direct bilirubin levels affected prognosis (p = 0.000). Alcohol-related liver disease was the main cause (41.8%). Higher MELD scores were linked to worse outcomes; etiology and hospitalization duration (p = 0.138) had no significant effect on outcomes. Conclusion: This study provides valuable insights into HE in liver disease patients, facilitating early detection and effective management to reduce mortality and morbidity rates.

Details

Language :
English
ISSN :
22314261
Volume :
13
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of Krishna Institute of Medical Sciences University
Publication Type :
Academic Journal
Accession number :
edsdoj.f8b0891611b44d6caa9c24f5749b1a92
Document Type :
article