Application of anti-HBc quantitative examination in clinical management of chronic hepatitis B virus infection

The quantification of hepatitis B virus(HBV) core antibody (anti-HBc) is related to host immunity and can be detected in the serum of patients with current or past infections. The antibody against core antigen of HBV plays an important role in the inflammation pathogenesis of liver,evaluation of epidemiology history and of treatment strategy. Chronic HBV infection is closely related to active transcription and persistence of covalently closed circular DNA(cccDNA) in the liver. The result of quantitative anti-HBc antibody examination shows a good correlation with cccDNA level so it is a potential index for comprehensive evaluation of HBV infectious diseases.