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The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance

Authors :
Chen Zhong
Guojuan Wang MD
Min Guo
Naicheng Zhu
Xiudan Chen
Yuwei Yan
Nanxin Li
Wenyan Yu MD
Source :
Cancer Control, Vol 31 (2024)
Publication Year :
2024
Publisher :
SAGE Publishing, 2024.

Abstract

Background: Colorectal cancer is a major cause of mortality among the prevalent malignant tumors of the gastrointestinal tract. Although chemotherapy is a standard treatment for colorectal cancer, its efficacy is limited by chemoresistance. Recent studies have investigated targeting tumor stem cells as a potential new therapeutic approach for addressing chemoresistance in colorectal cancer. Colorectal cancer frequently relapses, with tumor stem cells often representing one of the leading causes of treatment failure. Purpose: Understanding drug resistance in colorectal cancer stem cells is crucial for improving treatment outcomes. By focusing on developing targeted therapies that specifically address drug resistance in colorectal cancer stem cells, there is potential to make significant advancements in the treatment of colorectal cancer.This approach may lead to more effective and lasting outcomes in patients battling colorectal cancer. Research Design: In this review, a comprehensive overview of recent research on colorectal cancer stem cell treatment resistance is presented.Results: Elucidating the key underlying mechanisms. This review also highlights the potential benefits of targeted therapies in overcoming colorectal cancer resistance to treatment. Conclusions: CCSCs are key players in drug resistance of CRC, indicating their potential as targets for effective therapy. Elucidating their role in this process could aid in discovering tailored treatment strategies.The significance of signaling pathways, TME, and miRNA in regulating drug resistance in CCSCs is been highlighted.

Details

Language :
English
ISSN :
15262359 and 10732748
Volume :
31
Database :
Directory of Open Access Journals
Journal :
Cancer Control
Publication Type :
Academic Journal
Accession number :
edsdoj.f8580adf9778480babbf6681bff969e2
Document Type :
article
Full Text :
https://doi.org/10.1177/10732748241274196