EKSPRESI PROTEIN GEN NM23 PADA KARSINOMA SEL SKUAMOSA LIDAH

Tongue squamous cell carcinoma, a relatively frequent malignancy in the oral cavity, has a great tendency to metastasize to regional lymph nodes that worsens the prognosis of the disease. The anti metastasis gene NM23, encodes a 17 KD cytoplasmic and nuclear proteins, has shown controversy behavior as metastatis supressor in human cancer. An observational study using immunohistochemical staining method with LSAB (-) technique was conducted on 41 paraffin block specimens to show the relationship between significance of the expression of NM23 protein as a marker for cancer metastasis and the staging, cancer grading, and the positive regional head and neck lymph nodes. Statistical significance of difference was evaluated using Chi square test (p