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Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment

Authors :
Yingpeng Li
Liang Liu
Hongtao Shang
Xuchen Feng
Ni Fan
Jingyu Wang
Yuqi Wu
Yatong Chen
Xinhong Chu
Min Zhong
Yujiao Sun
Hui Fu
Wei Huang
Yunfei Li
Source :
Pharmaceutics, Vol 14, Iss 11, p 2461 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Triple-negative breast cancer (TNBC) has been listed as one of the most fatal diseases, and no effective targeting treatment is clinically available. Although CD44-targeting hyaluronic acid (HA) has been utilized as targeting ligands in many studies, no facile ways have been developed through HA self-assembly at the nanoparticle surface. Herein, we reported N-isopropylacrylamide-grafted chitosan-based nanoparticles self-assembling with HA (HA-NPs) through electrostatic forces and loaded with curcumin (CUR). The HA-NPs displayed pH-responsive properties due to the chemical modification of chitosan, and the preparation process was optimized by central composite design–response surface methodology. HA anchorage confers the vehicle with tumor-targeting capability. HA-NPs displayed more robust effects of inhibiting TNBC primary tumor growth than free CUR and a plain counterpart but without increased systemic cytotoxicity. In addition, in vivo pharmacokinetic studies showed that HA-NPs significantly increased the in vivo residence time of free CUR and improved the bioavailability of CUR. These findings suggested that chitosan-based HA-NPs may provide a feasible and unique strategy to achieve CD44 targeting and enhance its efficacy in vivo for the treatment of advanced TNBC.

Details

Language :
English
ISSN :
19994923
Volume :
14
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.f802a953c9c346ac89ef07b4dc23cb08
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics14112461