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Small Molecule Library Synthesis Using Segmented Flow

Authors :
Christina M. Thompson
Stevan W. Djuric
Jeffrey L. Cross
Irini Akritopoulou-Zanze
Jennifer L. Poole
Source :
Molecules, Vol 16, Iss 11, Pp 9161-9177 (2011)
Publication Year :
2011
Publisher :
MDPI AG, 2011.

Abstract

Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this paper we describe a method that adapts flow chemistry to the synthesis of libraries of compounds using a fluorous immiscible solvent as a spacer between reactions. The methodology was validated in the synthesis of two small heterocycle containing libraries. The reactions were performed on a 0.2 mmol scale, enabling tens of milligrams of material to be generated in a single 200 mL reaction plug. The methodology allowed library synthesis in half the time of conventional microwave synthesis while maintaining similar yields. The ability to perform multiple, potentially unrelated reactions in a single run is ideal for making small quantities of many different compounds quickly and efficiently.

Details

Language :
English
ISSN :
14203049
Volume :
16
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.f7d238b71f4c36b97d242e10bb77bd
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules16119161