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Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections

Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections

Authors :
Jennifer Molle
Sarah Duponchel
Jennifer Rieusset
Michel Ovize
Alexander V. Ivanov
Fabien Zoulim
Birke Bartosch
Source :
Viruses, Vol 17, Iss 1, p 11 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the context of many viral infections including chronic hepatitis B and C. Cyps are a group of enzymes with peptidyl-prolyl isomerase activity (PPIase), known to be required for replication of diverse viruses including hepatitis B and C viruses (HBV and HCV). Amongst the Cyp family, the molecular mechanisms underlying the antiviral effects of CypA have been investigated in detail, but potential roles of other Cyps are less well studied in the context of viral hepatitis. Furthermore, most studies investigating the role of Cyps in viral hepatitis did not investigate the potential therapeutic effects of their inhibition in already-established infections but have rather been performed in the context of neo-infections. Here, we investigated the effects of genetically silencing Cyps on persistent HCV and HBV infections. We confirm antiviral effects of CypA and CypD knock down and demonstrate novel roles for CypG and CypH in HCV replication. We show, furthermore, that CypA silencing has a modest but reproducible impact on persistent HBV infections in cultured human hepatocytes.

Details

Language :
English
ISSN :
19994915
Volume :
17
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.f7ca861bdd04d93b4993b1b14dd287b
Document Type :
article
Full Text :
https://doi.org/10.3390/v17010011