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Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes
- Source :
- Journal of Functional Foods, Vol 91, Iss , Pp 105014- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- We evaluated the impact of 6-month probiotics and calcium supplementation at 1–6 years of age on neurodevelopment in adolescence, along with the effects of other biomedical and socioenvironmental factors. We re-enrolled 238 adolescents 10-years after supplementation with low-lactose milk with either low calcium (LC; ∼50 mg/d; n = 53), regular calcium (RC; ∼440 mg/d; n = 70), RC with 5x108 CFU/d Lactobacillus reuteri DSM17938 (reuteri; n = 55), or RC with 5x108 CFU/d L. casei CRL431 (casei; n = 60). Compared to RC, the casei group scored 0.38 SD (effect size, 0.04–0.72) higher on the Raven’s Progressive Matrices; the reuteri group was 0.38 SD (0.01–0.75) lower on the Children’s Depression Inventory; and the LC and younger adolescents in the reuteri group were 0.36 (0.01–0.71) and 0.49 SD (0.02–0.95) lower in brain-derived neurotrophic factor. Diet quality, physical activity, and home environment contributed similar effect sizes. Probiotics supplementation in childhood have strain-specific long-term neurodevelopmental benefits and integration with socioenvironmental interventions are warranted.
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 91
- Issue :
- 105014-
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Functional Foods
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f7965c7ca5024e78ab4c447c039b6f5c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jff.2022.105014