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The ERG1 K+ Channel and Its Role in Neuronal Health and Disease
- Source :
- Frontiers in Molecular Neuroscience, Vol 15 (2022)
- Publication Year :
- 2022
- Publisher :
- Frontiers Media S.A., 2022.
-
Abstract
- The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1’s relationship to the mammalian brain and highlights key questions that have yet to be answered.
Details
- Language :
- English
- ISSN :
- 16625099
- Volume :
- 15
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Molecular Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f781e34a461b436cba5f92c403c556ee
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fnmol.2022.890368