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Antioxidant and anti-aging role of silk sericin in D-galactose induced mice model
- Source :
- Saudi Journal of Biological Sciences, Vol 30, Iss 12, Pp 103872- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- The main purpose was to elucidate the potential anti-aging impact of sericin, due to its anti-oxidant potential in D-galactose induced mice model. To induce natural aging in mice, a solution of 0.9 % saline containing D-galactose (250 mg/kg b.w.) was injected intraperitoneally for a period of 60 days. In this experiment, 56 male mice were arbitrarily categorized into 8 groups (1: control; 2: D-Galactose (250 mg/kg b.w), Group 3: Sericin (150 mg/kg b.w), Group 4: Metformin (150 mg/kg), Group 5: sericin (P), Group 6; sericin (T), Group 7; Met (P), Group 8; Met (T). The level of Glutathione reductase (2.1 ± 0.2 µmol/L), CAT (0.5 ± 0.0 mmol/mL), Superoxide dismutase (65.4 ± 1.7 U/mL), GSHPx (69.2 ± 1.7 U/l), T3 (3.1 ± 0.7 ng/mL), IL-2 (68.8 ± 1.5 Pg/mL), IL-4 (71.4 ± 4.2 Pg/mL), IgG (0.6 ± 0.0 mg/mL) and IgM (0.6 ± 0.0 mg/mL) were significantly (P
Details
- Language :
- English
- ISSN :
- 1319562X
- Volume :
- 30
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Saudi Journal of Biological Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f778161316e41bfa2a5e63230cdaf1d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.sjbs.2023.103872